Pharmacological targeting of mitochondrial reactive oxygen species counteracts diaphragm weakness in chronic heart failure

Diaphragm muscle weakness in chronic heart failure (CHF) is caused by elevated oxidants and exacerbates breathing abnormalities, exercise intolerance, and dyspnea. However, the specific source of oxidants that cause diaphragm weakness is unknown. We examined whether mitochondrial reactive oxygen spe...

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Publicat a:J Appl Physiol (1985)
Autors principals: Laitano, Orlando, Ahn, Bumsoo, Patel, Nikhil, Coblentz, Philip D., Smuder, Ashley J., Yoo, Jeung-Ki, Christou, Demetra D., Adhihetty, Peter J., Ferreira, Leonardo F.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824042/
https://ncbi.nlm.nih.gov/pubmed/26846552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00822.2015
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