GW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling

PGE2, the major product of cyclooxygenases implicated in carcinogenesis, is significantly upregulated in cervical cancer. PGE2 via prostanoid receptor EP4 stimulates proliferation and motility while inhibiting apoptosis and immune surveillance. It promotes angiogenesis by stimulating the production...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Parida, S, Pal, I, Parekh, A, Thakur, B, Bharti, R, Das, S, Mandal, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823960/
https://ncbi.nlm.nih.gov/pubmed/27010855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.61
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