GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP(4) receptor antagonist

1. N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl}benzene sulphonamide (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP(4) receptors with additional human TP receptor affinity. 2. At recombinant human prostanoid EP(4) receptors expr...

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Autors principals: Wilson, Richard J, Giblin, Gerard M P, Roomans, Susan, Rhodes, Sharron A, Cartwright, Kerri-Ann, Shield, Vanessa J, Brown, Jason, Wise, Alan, Chowdhury, Jannatara, Pritchard, Sara, Coote, Jim, Noel, Lloyd S, Kenakin, Terry, Burns-Kurtis, Cynthia L, Morrison, Valerie, Gray, David W, Giles, Heather
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2006
Matèries:
Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751567/
https://ncbi.nlm.nih.gov/pubmed/16604093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706726
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