Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model

Prostaglandin E2, the major COX-2 product, acts via 4 functionally distinct prostanoid receptors, EP(1–4). PGE-2, through its receptors, feeds back to positively increase COX-2 expression augmenting its own synthesis thereby driving angiogenesis, while suppressing apoptosis and innate immunity. In a...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Parida, Sheetal, Parekh, Aditya, Dey, Goutam, Ghosh, Sukhen C, Mandal, Mahitosh
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623220/
https://ncbi.nlm.nih.gov/pubmed/25894216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1040953
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