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4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptio...
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| Publicado no: | Genome Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4823877/ https://ncbi.nlm.nih.gov/pubmed/27052789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0923-2 |
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