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Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma
The BCL6 oncogene plays a crucial role in sustaining diffuse large B-cell lymphomas (DLBCL) through transcriptional repression of key checkpoint genes. BCL6-targeted therapy kills lymphoma cells by releasing these checkpoints. However BCL6 also directly represses several DLBCL oncogenes such as BCL2...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Oncotarget |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Impact Journals LLC
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4823124/ https://ncbi.nlm.nih.gov/pubmed/26657288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6513 |
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