Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma

The BCL6 oncogene plays a crucial role in sustaining diffuse large B-cell lymphomas (DLBCL) through transcriptional repression of key checkpoint genes. BCL6-targeted therapy kills lymphoma cells by releasing these checkpoints. However BCL6 also directly represses several DLBCL oncogenes such as BCL2...

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Vydáno v:Oncotarget
Hlavní autoři: Dupont, Thibault, Yang, ShaoNing, Patel, Jayeshkumar, Hatzi, Katerina, Malik, Alka, Tam, Wayne, Martin, Peter, Leonard, John, Melnick, Ari, Cerchietti, Leandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823124/
https://ncbi.nlm.nih.gov/pubmed/26657288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6513
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