The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells

Both erbB3 and IGF-1 receptor (IGF-1R) have been shown to play an important role in trastuzumab resistance. However, it remains unclear whether erbB3- and IGF-1R-initiated signaling pathways possess distinct effects on the sensitivity of lapatinib, a dual tyrosine kinase inhibitor against both EGFR...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Lyu, Hui, Yang, Xiao He, Edgerton, Susan M., Thor, Ann D., Wu, Xiaoying, He, Zhimin, Liu, Bolin
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823081/
https://ncbi.nlm.nih.gov/pubmed/26621843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6404
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