The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells

BACKGROUND: Elevated expression of erbB3 receptor has been reported to induce resistance to therapeutic agents, including trastuzumab in erbB2-overexpressing breast cancer. Our recent studies indicate that erbB3 interacts with both erbB2 and IGF-1 receptor to form a heterotrimeric complex in trastuz...

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Main Authors: Huang, Jingcao, Wang, Shuiliang, Lyu, Hui, Cai, Bo, Yang, XiaoHe, Wang, Jianxiang, Liu, Bolin
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829386/
https://ncbi.nlm.nih.gov/pubmed/24215614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-134
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