LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

We analyzed the mechanism underlying 5-aminoimidazole-4-carboxamide riboside (AICAR) mediated apoptosis in LKB1-null non-small cell lung cancer (NSCLC) cells. Metabolic profile analysis revealed depletion of the intracellular pyrimidine pool after AICAR treatment, but uridine was the only nucleotide...

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Pubblicato in:Oncotarget
Autori principali: Liu, Fakeng, Jin, Rui, Liu, Xiuju, Huang, Henry, Wilkinson, Scott C., Zhong, Diansheng, Khuri, Fadlo R., Fu, Haian, Marcus, Adam, He, Yulong, Zhou, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823052/
https://ncbi.nlm.nih.gov/pubmed/26506235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6224
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