Inhibition of IGF1R enhances 2-deoxyglucose in the treatment of non-small cell lung cancer

OBJECTIVE: We previously postulated that 2-deoxyglucose (2-DG) activates multiple pro-survival pathways through IGF1R to negate its inhibitory effect on glycolysis. Here, we evaluated whether IGF1R inhibitor synergizes with 2-DG to impede the growth of non-small cell lung cancer (NSCLC). MATERIALS A...

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Publicado no:Lung Cancer
Main Authors: Liu, Fakeng, Liu, Yuan, Liu, Xiuju, Mao, Kaisheng, Zhong, Diansheng, Marcus, Adam I., Khuri, Fadlo R., Sun, Shi-Yong, He, Yulong, Zhou, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447049/
https://ncbi.nlm.nih.gov/pubmed/30089593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2018.06.026
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