The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R

Recent molecular studies indicate that aerobic glycolysis plays an important role in tumorigenesis and is a valid target for cancer therapy. Although 2-deoxyglucose (2-DG) is well characterized as a glycolytic inhibitor, we recently discovered that it activates a prosurvival oncoprotein, AKT, throug...

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Detalhes bibliográficos
Main Authors: Zhong, Diansheng, Xiong, Li, Liu, Tongrui, Liu, Xiuju, Liu, Xiangguo, Chen, Jing, Sun, Shi-Yong, Khuri, Fadlo R., Zong, Yaping, Zhou, Qinghua, Zhou, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749096/
https://ncbi.nlm.nih.gov/pubmed/19574224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005280
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