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LKB1 is Necessary for Akt-mediated Phosphorylation of Pro-apoptotic Proteins
LKB1 plays the role of tumor suppressor, opposite to Akt, by negatively regulating mTOR through the activation of AMPK and TSC signaling. We have discovered a novel, potentially oncogenic role for LKB1, as a supporter of Akt-mediated phosphorylation of pro-apoptotic proteins. We found that Akt activ...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596073/ https://ncbi.nlm.nih.gov/pubmed/18794113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1484 |
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