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Inhibition of IGF1R enhances 2-deoxyglucose in the treatment of non-small cell lung cancer
OBJECTIVE: We previously postulated that 2-deoxyglucose (2-DG) activates multiple pro-survival pathways through IGF1R to negate its inhibitory effect on glycolysis. Here, we evaluated whether IGF1R inhibitor synergizes with 2-DG to impede the growth of non-small cell lung cancer (NSCLC). MATERIALS A...
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| 出版年: | Lung Cancer |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447049/ https://ncbi.nlm.nih.gov/pubmed/30089593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2018.06.026 |
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