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Inhibition of IGF1R enhances 2-deoxyglucose in the treatment of non-small cell lung cancer

OBJECTIVE: We previously postulated that 2-deoxyglucose (2-DG) activates multiple pro-survival pathways through IGF1R to negate its inhibitory effect on glycolysis. Here, we evaluated whether IGF1R inhibitor synergizes with 2-DG to impede the growth of non-small cell lung cancer (NSCLC). MATERIALS A...

詳細記述

保存先:
書誌詳細
出版年:Lung Cancer
主要な著者: Liu, Fakeng, Liu, Yuan, Liu, Xiuju, Mao, Kaisheng, Zhong, Diansheng, Marcus, Adam I., Khuri, Fadlo R., Sun, Shi-Yong, He, Yulong, Zhou, Wei
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447049/
https://ncbi.nlm.nih.gov/pubmed/30089593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2018.06.026
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