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TIF-IA: an oncogenic target of pre-ribosomal RNA synthesis

Cancer cells devote the majority of their energy consumption to ribosome biogenesis, and pre-ribosomal RNA transcription accounts for 30–50% of all transcriptional activity. This aberrantly elevated biological activity is an attractive target for cancer therapeutic intervention if approaches can be...

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Publicat a:Biochim Biophys Acta
Autors principals: Jin, Rui, Zhou, Wei
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138081/
https://ncbi.nlm.nih.gov/pubmed/27641688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2016.09.003
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