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Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA
Transcription initiation factor I (TIF-IA) plays an essential role in regulating ribosomal RNA (rRNA) synthesis by tethering RNA polymerase I (Pol I) to the rDNA promoter. We have found that activated Akt enhances rRNA synthesis through the phosphorylation of casein kinase IIα (CK2α) on a threonine...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870716/ https://ncbi.nlm.nih.gov/pubmed/24297901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313097110 |
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