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Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1
Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, an effective immunosuppressive drug. Both MPA and mycophenolate mofetil are highly specific inhibitors of guanine nucleotide synthesis and of T-cell activation. However, the mechanism by which guanine nucleotide depletion sup...
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| Publicado no: | Blood |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4400289/ https://ncbi.nlm.nih.gov/pubmed/25691158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-616433 |
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