GUANINE NUCLEOTIDE DEPLETION INHIBITS PRE-RIBOSOMAL RNA SYNTHESIS AND CAUSES NUCLEOLAR DISRUPTION

Inosine monophosphate dehydrogenase (IMPDH) is a pivotal enzyme in the de novo pathway of guanine nucleotide biosynthesis. Inhibitors of this enzyme decrease intracellular guanine nucleotide levels by 50-80% and have potential as anti-neoplastic agents. Both mycophenolic acid (MPA) and AVN-944 are h...

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Pubblicato in:Leuk Res
Autori principali: Huang, Min, Ji, Yanshan, Itahana, Koji, Zhang, Yanping, Mitchell, Beverly
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552191/
https://ncbi.nlm.nih.gov/pubmed/17462731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2007.03.025
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