Lataa...
GUANINE NUCLEOTIDE DEPLETION INHIBITS PRE-RIBOSOMAL RNA SYNTHESIS AND CAUSES NUCLEOLAR DISRUPTION
Inosine monophosphate dehydrogenase (IMPDH) is a pivotal enzyme in the de novo pathway of guanine nucleotide biosynthesis. Inhibitors of this enzyme decrease intracellular guanine nucleotide levels by 50-80% and have potential as anti-neoplastic agents. Both mycophenolic acid (MPA) and AVN-944 are h...
Tallennettuna:
| Julkaisussa: | Leuk Res |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2007
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4552191/ https://ncbi.nlm.nih.gov/pubmed/17462731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2007.03.025 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|