Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation

Colorectal cancer is the third most frequently diagnosed cancer worldwide. Prevention of colorectal cancer initiation represents the most effective overall strategy to reduce its associated morbidity and mortality. Activating KRAS mutation (KRAS(mut)) is the most prevalent oncogenic driver in colore...

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Опубликовано в: :Oncotarget
Главные авторы: Le Rolle, Anne-France, Chiu, Thang K., Zeng, Zhaoshi, Shia, Jinru, Weiser, Martin R., Paty, Philip B., Chiu, Vi K.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
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Priority Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823026/
https://ncbi.nlm.nih.gov/pubmed/26744320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6818
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