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Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells
How oncogenes modulate the self-renewal properties of cancer-initiating cells is incompletely understood. Activating KRAS and NRAS mutations are among the most common oncogenic lesions detected in human cancer, and occur in myeloproliferative disorders (MPDs) and leukemias. We investigated the effec...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656550/ https://ncbi.nlm.nih.gov/pubmed/19296721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000059 |
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