JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal

Loss of the JunB/AP-1 transcription factor induces a myeloproliferative disease (MPD) arising from the hematopoietic stem cell (HSC) compartment. Now we show that JunB inactivation deregulates the cell cycle machinery and increases the proliferation of long-term repopulating HSCs (LT-HSCs) without i...

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Hlavní autoři: Santaguida, Marianne, Schepers, Koen, King, Bryan, Sabnis, Amit J., Forsberg, E. Camilla, Attema, Joanne L., Braun, Benjamin S., Passegué, Emmanuelle
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669108/
https://ncbi.nlm.nih.gov/pubmed/19345332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.02.016
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