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EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer

PURPOSE: Genetic variability in KRAS and EGFR predicts response to cetuximab in irinotecan refractory colorectal cancer. Whether these markers or others remain predictive in combination biologic therapies including bevacizumab is unknown. We identified predictive biomarkers from patients with irinot...

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Detalhes bibliográficos
Publicado no:Pathol Oncol Res
Main Authors: Khan, Sajid A., Zeng, Zhaoshi, Shia, Jinru, Paty, Philip B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451302/
https://ncbi.nlm.nih.gov/pubmed/28025786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12253-016-0166-2
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