Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It processes host pre-mRNAs to serve as primers for viral mRNA and is an attractive target for antiinfluenza drug discovery. Compound L-742,001 is a prototypical endonuclease inhibitor, and we found that repeated passa...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Song, Min-Suk, Kumar, Gyanendra, Shadrick, William R., Zhou, Wei, Jeevan, Trushar, Li, Zhenmei, Slavish, P. Jake, Fabrizio, Thomas P., Yoon, Sun-Woo, Webb, Thomas R., Webby, Richard J., White, Stephen W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822642/
https://ncbi.nlm.nih.gov/pubmed/26976575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519772113
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker