Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Emerging influenza viruses are a serious threat to human health because of their pandemic potential. A promising target for the development of novel anti-influenza therapeutics is the PA protein, whose endonuclease activity is essential for viral replication. Translation of viral mRNAs by the host r...

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Main Authors: DuBois, Rebecca M., Slavish, P. Jake, Baughman, Brandi M., Yun, Mi-Kyung, Bao, Ju, Webby, Richard J., Webb, Thomas R., White, Stephen W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410894/
https://ncbi.nlm.nih.gov/pubmed/22876176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002830
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