Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It processes host pre-mRNAs to serve as primers for viral mRNA and is an attractive target for antiinfluenza drug discovery. Compound L-742,001 is a prototypical endonuclease inhibitor, and we found that repeated passa...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Song, Min-Suk, Kumar, Gyanendra, Shadrick, William R., Zhou, Wei, Jeevan, Trushar, Li, Zhenmei, Slavish, P. Jake, Fabrizio, Thomas P., Yoon, Sun-Woo, Webb, Thomas R., Webby, Richard J., White, Stephen W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2016
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822642/
https://ncbi.nlm.nih.gov/pubmed/26976575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519772113
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