Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress

BACKGROUND: Anomalies in myocardial structure involving myocyte growth, hypertrophy, differentiation, apoptosis, necrosis etc. affects its function and render cardiac tissue more vulnerable to the development of heart failure. Although oxidative stress has a well-established role in cardiac remodeli...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Kumar, Radhakrishnan Rajesh, Narasimhan, Madhusudhanan, Shanmugam, Gobinath, Hong, Jennifer, Devarajan, Asokan, Palaniappan, Sethu, Zhang, Jianhua, Halade, Ganesh V., Darley-Usmar, Victor M., Hoidal, John R., Rajasekaran, Namakkal S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822244/
https://ncbi.nlm.nih.gov/pubmed/27048381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0839-3
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