Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1), especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies. Cell-based studies demonstrated that these mutants confer ERα constitutive activity and antiestrogen resistance and suggest that ligand-bind...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2016
Konular:
Structural Biology and Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821807/
https://ncbi.nlm.nih.gov/pubmed/26836308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12792
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller