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Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

Down syndrome (DS) is a common cause of intellectual disability and is also associated with early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21, most adults over 40 years old with DS have beta-amyloid plaques as a result of overexpression of the amyloid precurs...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Wilcock, Donna M., Schmitt, Frederick A., Head, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821721/
https://ncbi.nlm.nih.gov/pubmed/26593849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.11.007
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