Myeloid-derived suppressor cell survival and function are regulated by the transcription factor Nrf2()

Tumor-induced myeloid-derived suppressor cells (MDSC) contribute to immune suppression in tumor-bearing individuals and are a major obstacle to effective immunotherapy. Reactive oxygen species (ROS) are one of the mechanisms used by MDSC to suppress T cell activation. Although ROS are toxic to most...

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Veröffentlicht in:J Immunol
Hauptverfasser: Beury, Daniel W., Carter, Kayla A., Nelson, Cassandra, Sinha, Pratima, Hanson, Erica, Nyandjo, Maeva, Fitzgerald, Phillip J., Majeed, Amry, Wali, Neha, Ostrand-Rosenberg, Suzanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821672/
https://ncbi.nlm.nih.gov/pubmed/26936880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501785
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