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Myeloid-derived suppressor cell survival and function are regulated by the transcription factor Nrf2()
Tumor-induced myeloid-derived suppressor cells (MDSC) contribute to immune suppression in tumor-bearing individuals and are a major obstacle to effective immunotherapy. Reactive oxygen species (ROS) are one of the mechanisms used by MDSC to suppress T cell activation. Although ROS are toxic to most...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4821672/ https://ncbi.nlm.nih.gov/pubmed/26936880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501785 |
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