mTOR inhibition by rapamycin increases ceramide synthesis by promoting transforming growth factor‐β1/Smad signaling in the skin

Although mammalian target of rapamycin (mTOR) mediates a wide variety of biological functions, little information is available on the effect of mTOR on the functions of skin cells. In this study, we investigated effects of mTOR inhibition by rapamycin on ceramide synthesis in the skin of rats and hu...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Yamane, Takumi, Muramatsu, Aimi, Yoshino, Sawako, Matsui, Sho, Shimura, Mari, Tsujii, Yoshimasa, Iwatsuki, Ken, Kobayashi‐Hattori, Kazuo, Oishi, Yuichi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821357/
https://ncbi.nlm.nih.gov/pubmed/27239444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12039
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