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Production of biologically active IL‐36 family cytokines through insertion of N‐terminal caspase cleavage motifs

Recent evidence has strongly implicated IL‐36 cytokines as key initiators of inflammation in the skin barrier. IL‐36 cytokines belong to the extended IL‐1 family and, similar to most members of this family, are expressed as inactive precursors that require proteolytic processing for activation. Beca...

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Vydáno v:FEBS Open Bio
Hlavní autoři: Clancy, Danielle M., Henry, Conor M., Davidovich, Pavel B., Sullivan, Graeme P., Belotcerkovskaya, Ekaterina, Martin, Seamus J.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821354/
https://ncbi.nlm.nih.gov/pubmed/27239446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12044
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