Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication

PURPOSE: Reovirus is a naturally occurring oncolytic virus in clinical trials. Although tumor infection by reovirus can generate adaptive antitumor immunity, its therapeutic importance versus direct viral oncolysis is undefined. This study addresses the requirement for viral oncolysis and replicatio...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Prestwich, Robin J., Ilett, Elizabeth J., Errington, Fiona, Diaz, Rosa M., Steele, Lynette P., Kottke, Tim, Thompson, Jill, Galivo, Feorillo, Harrington, Kevin J., Pandha, Hardev S., Selby, Peter J., Vile, Richard G., Melcher, Alan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821072/
https://ncbi.nlm.nih.gov/pubmed/19509134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0334
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