Targeting the γ-Aminobutyric Acid A Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction

We previously demonstrated that airway smooth muscle (ASM) cells express γ-aminobutyric acid A receptors (GABA(A)Rs), and that GABA(A)R agonists acutely relax ASM. Among the GABA(A)R α subunits, human ASM cells express only α4 and α5, providing the opportunity for selective pharmacologic targeting....

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Dettagli Bibliografici
Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Yocum, Gene T., Gallos, George, Zhang, Yi, Jahan, Rajwana, Stephen, Michael Rajesh, Varagic, Zdravko, Puthenkalam, Roshan, Ernst, Margot, Cook, James M., Emala, Charles W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821055/
https://ncbi.nlm.nih.gov/pubmed/26405827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0176OC
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