Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension

Calpain mediates collagen synthesis and cell proliferation and plays an important role in pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). In the present study, we investigated whether and how calpain is activated by PAH mediators in pulmonary artery smooth muscle cells (PASMC...

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Détails bibliographiques
Publié dans:Am J Respir Cell Mol Biol
Auteurs principaux: Kovacs, Laszlo, Han, Weihong, Rafikov, Ruslan, Bagi, Zsolt, Offermanns, Stefan, Saido, Takaomi C., Black, Stephen M., Su, Yunchao
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2016
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821035/
https://ncbi.nlm.nih.gov/pubmed/26248159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0151OC
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