Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension

Calpain mediates collagen synthesis and cell proliferation and plays an important role in pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). In the present study, we investigated whether and how calpain is activated by PAH mediators in pulmonary artery smooth muscle cells (PASMC...

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Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Kovacs, Laszlo, Han, Weihong, Rafikov, Ruslan, Bagi, Zsolt, Offermanns, Stefan, Saido, Takaomi C., Black, Stephen M., Su, Yunchao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821035/
https://ncbi.nlm.nih.gov/pubmed/26248159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0151OC
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