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Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension

Calpain mediates collagen synthesis and cell proliferation and plays an important role in pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). In the present study, we investigated whether and how calpain is activated by PAH mediators in pulmonary artery smooth muscle cells (PASMC...

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Bibliografiske detaljer
Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Kovacs, Laszlo, Han, Weihong, Rafikov, Ruslan, Bagi, Zsolt, Offermanns, Stefan, Saido, Takaomi C., Black, Stephen M., Su, Yunchao
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821035/
https://ncbi.nlm.nih.gov/pubmed/26248159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0151OC
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