TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

BACKGROUND: Recent genome-wide association studies revealed TREM2 rs75932628-T variant to be associated with Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the role that TREM2 plays in sporadic AD is largely unknown. Our aim was to assess messenger RNA (mRNA) expression leve...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Celarain, Naiara, Sánchez-Ruiz de Gordoa, Javier, Zelaya, María Victoria, Roldán, Miren, Larumbe, Rosa, Pulido, Laura, Echavarri, Carmen, Mendioroz, Maite
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820985/
https://ncbi.nlm.nih.gov/pubmed/27051467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0202-9
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