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Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering
Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilit...
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| I publikationen: | Nat Commun |
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| Huvudupphovsmän: | , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4820933/ https://ncbi.nlm.nih.gov/pubmed/27025571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11126 |
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