A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host

BACKGROUND: Hepatitis C virus (HCV) could induce chronic liver diseases and hepatocellular carcinoma in human. The use of primary human hepatocyte as a viral host is restrained with the scarcity of tissue supply. A culture model restricted to HCV genotype 2a (JFH-1) has been established using Huh7-d...

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Vydáno v:Virol J
Hlavní autoři: Sa-ngiamsuntorn, Khanit, Wongkajornsilp, Adisak, Phanthong, Phetcharat, Borwornpinyo, Suparerk, Kitiyanant, Narisorn, Chantratita, Wasun, Hongeng, Suradej
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820862/
https://ncbi.nlm.nih.gov/pubmed/27044429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-016-0519-1
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