In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin

[Image: see text] Thiopeptides are potent antibiotics that inhibit protein synthesis. They are made by a remarkable post-translational modification process that transforms a linear peptide into a polycyclic structure. We present here the in vitro biosynthesis of the core scaffold of thiomuracin cata...

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Udgivet i:J Am Chem Soc
Main Authors: Hudson, Graham A., Zhang, Zhengan, Tietz, Jonathan I., Mitchell, Douglas A., van der Donk, Wilfred A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819586/
https://ncbi.nlm.nih.gov/pubmed/26675417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10194
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