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Use of a Scaffold Peptide in the Biosynthesis of Amino Acid Derived Natural Products

Genome sequencing of environmental bacteria allows identification of biosynthetic gene clusters encoding unusual combinations of enzymes that produce unknown natural products. We identified a pathway in which a ribosomally synthesized small peptide serves as a scaffold for non-ribosomal peptide exte...

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Publicat a:Science
Autors principals: Ting, Chi P., Funk, Michael A., Halaby, Steve L., Zhang, Zhengan, Gonen, Tamir, van der Donk, Wilfred A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686864/
https://ncbi.nlm.nih.gov/pubmed/31320540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau6232
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