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Use of a Scaffold Peptide in the Biosynthesis of Amino Acid Derived Natural Products

Genome sequencing of environmental bacteria allows identification of biosynthetic gene clusters encoding unusual combinations of enzymes that produce unknown natural products. We identified a pathway in which a ribosomally synthesized small peptide serves as a scaffold for non-ribosomal peptide exte...

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Publicado en:Science
Autores principales: Ting, Chi P., Funk, Michael A., Halaby, Steve L., Zhang, Zhengan, Gonen, Tamir, van der Donk, Wilfred A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686864/
https://ncbi.nlm.nih.gov/pubmed/31320540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau6232
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