The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

Expression of the initiator methionine tRNA (tRNA(i)(Met)) is deregulated in cancer. Despite this fact, it is not currently known how tRNA(i)(Met) expression levels influence tumor progression. We have found that tRNA(i)(Met) expression is increased in carcinoma-associated fibroblasts, implicating d...

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Publicado no:Curr Biol
Main Authors: Clarke, Cassie J., Berg, Tracy J., Birch, Joanna, Ennis, Darren, Mitchell, Louise, Cloix, Catherine, Campbell, Andrew, Sumpton, David, Nixon, Colin, Campbell, Kirsteen, Bridgeman, Victoria L., Vermeulen, Peter B., Foo, Shane, Kostaras, Eleftherios, Jones, J. Louise, Haywood, Linda, Pulleine, Ellie, Yin, Huabing, Strathdee, Douglas, Sansom, Owen, Blyth, Karen, McNeish, Iain, Zanivan, Sara, Reynolds, Andrew R., Norman, Jim C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819511/
https://ncbi.nlm.nih.gov/pubmed/26948875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.01.045
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