Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is a...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Hernandez-Fernaud, Juan R., Ruengeler, Elena, Casazza, Andrea, Neilson, Lisa J., Pulleine, Ellie, Santi, Alice, Ismail, Shehab, Lilla, Sergio, Dhayade, Sandeep, MacPherson, Iain R., McNeish, Iain, Ennis, Darren, Ali, Hala, Kugeratski, Fernanda G., Al Khamici, Heba, van den Biggelaar, Maartje, van den Berghe, Peter V.E., Cloix, Catherine, McDonald, Laura, Millan, David, Hoyle, Aoisha, Kuchnio, Anna, Carmeliet, Peter, Valenzuela, Stella M., Blyth, Karen, Yin, Huabing, Mazzone, Massimiliano, Norman, Jim C., Zanivan, Sara
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316871/
https://ncbi.nlm.nih.gov/pubmed/28198360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14206
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