Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

A152T‐variant human tau (hTau‐A152T) increases risk for tauopathies, including Alzheimer's disease. Comparing mice with regulatable expression of hTau‐A152T or wild‐type hTau (hTau‐WT), we find age‐dependent neuronal loss, cognitive impairments, and spontaneous nonconvulsive epileptiform activi...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Maeda, Sumihiro, Djukic, Biljana, Taneja, Praveen, Yu, Gui‐Qiu, Lo, Iris, Davis, Allyson, Craft, Ryan, Guo, Weikun, Wang, Xin, Kim, Daniel, Ponnusamy, Ravikumar, Gill, T Michael, Masliah, Eliezer, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818780/
https://ncbi.nlm.nih.gov/pubmed/26931567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541438
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