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Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice
A152T‐variant human tau (hTau‐A152T) increases risk for tauopathies, including Alzheimer's disease. Comparing mice with regulatable expression of hTau‐A152T or wild‐type hTau (hTau‐WT), we find age‐dependent neuronal loss, cognitive impairments, and spontaneous nonconvulsive epileptiform activi...
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| Udgivet i: | EMBO Rep |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818780/ https://ncbi.nlm.nih.gov/pubmed/26931567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541438 |
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