Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis

BACKGROUND: CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is beneficial in animal models of arthritis. The objective of this study was to determine the relative contributions of CSF-1 and IL-34 sign...

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Bibliografische gegevens
Gepubliceerd in:Arthritis Res Ther
Hoofdauteurs: Garcia, Samuel, Hartkamp, Linda M., Malvar-Fernandez, B, van Es, Inge E., Lin, Haishan, Wong, Justin, Long, Li, Zanghi, James A., Rankin, Andrew L., Masteller, Emma L., Wong, Brian R., Radstake, Timothy R. D. J., Tak, Paul P., Reedquist, Kris A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818474/
https://ncbi.nlm.nih.gov/pubmed/27036883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0973-6
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