Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression

OBJECTIVES: Epigenetic modifications play an important role in the regulation of gene transcription and cellular function. Here, we examined if pro-inflammatory factors present in the inflamed joint of patients with rheumatoid arthritis (RA) could regulate histone deacetylase (HDAC) expression and f...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Angiolilli, Chiara, Grabiec, Aleksander M, Ferguson, Bradley S, Ospelt, Caroline, Fernandez, Beatriz Malvar, van Es, Inge E, van Baarsen, Lisa G M, Gay, Steffen, McKinsey, Timothy A, Tak, Paul P, Baeten, Dominique L, Reedquist, Kris A
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336378/
https://ncbi.nlm.nih.gov/pubmed/25452308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-205635
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