Vectofusin-1, a New Viral Entry Enhancer, Strongly Promotes Lentiviral Transduction of Human Hematopoietic Stem Cells

Gene transfer into hCD34(+) hematopoietic stem/progenitor cells (HSCs) using human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) has several promising therapeutic applications. Yet, efficiency, safety, and cost of LV gene therapy could be ameliorated by enhancing target cell t...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Fenard, David, Ingrao, Dina, Seye, Ababacar, Buisset, Julien, Genries, Sandrine, Martin, Samia, Kichler, Antoine, Galy, Anne
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Methods - Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817938/
https://ncbi.nlm.nih.gov/pubmed/23653154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.17
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